We previously reported lower expression of key obesogenic factors in VAT from HF-EPA mice compared to HF group, such as plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein 1 (MCP-1) at protein levels [5], Galectin-3 in macrophages (Lgals3), Bone morphogenic protein 4 (Bmp4), CCAAT-enhancer binding protein alpha (Cebpa), Leptin (Lep) and Sterol Regulatory Element Binding Transcription Factor 1 (Srebf1) in mRNA levels [6]. The gene discussed is LEP; the disease is hydrops fetalis.