Similar considerations must be made for other potential markers identified by the same authors to be enriched in tumor-derived L-EVs, that is, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), glucose phosphate isomerase (GPI), lactate dehydrogenase B (LDHB) and heat shock protein 5 (HSPA5), which are almost ubiquitously expressed. The gene discussed is LDHB; the disease is neoplasm.