Laminopathies are the family of monogenic multi-system disorders that result from mutations in the LMNA gene, which encodes for nuclear lamins A and C. In the course of two decades, over 400 mutations in LMNA have been linked to various forms of laminopathies, including muscle dystrophies, cardiomyopathies, lipodystrophies, and neuropathies [1,2,3,4,5]. The gene discussed is LMNA; the disease is lipodystrophy.