In a clinical trial on “inflamm-ageing” and oxidative stress in healthy elderly subjects, the intake of 10 mg/kg of limonene as a food supplement in the context of a specific diet resulted in a decrease in fibrinogen, glucose, and insulin levels and in an amelioration of the HOMA-IR index, a homeostatic model assessment used to quantify insulin resistance and beta-cell function [109]. Here, INS is linked to Insulin resistance.