Moreover, it has been established that synthetic epi-miR, miR-29b oligonucleotides, potentiates a hypomethylating effect of DNMT1 inhibitors (decitabine or azacitidine) resulting in better AML response for treatment probably due to the inhibition of other DNMT isoforms that are not efficiently suppressed by these agents [69]. This evidence concerns the gene DNMT1 and acute myeloid leukemia.