POLN and breast cancer: As reported in the Catalogue of Somatic Mutation in Cancer (COSMIC) [18] database, NPL was overexpressed in 1.18% of BC cases (13/1104), POLN in 3.99% (44/1104), RASAL1 in 6.97% (77/1104) and ROS1 in 1.36% (15/1104).