We identified 15 proteins, which had lower plasma abundances in HIV-1-infected children; eight of these proteins including STAMBP, CD5, TFG-α, TRANCE, AXIN1, SIRT2, CD40 and IL-8 were also identified as classification predictors when a random forest classification algorithm was applied and the first five proteins (STAMBP, CD5, TFG-α, TRANCE, and AXIN1) in this group were the strongest prediction factors for treated HIV-1 infection. This evidence concerns the gene CD40 and HIV-1 infection.