SLC1A2 and depressive disorder: A study investigating the maladaptation of the glial glutamate transporter GLT-1 in changing the activity of lateral habenula neurons in an alcohol-withdrawal rat model found that systemic administration of ceftriaxone, an antibiotic known to increase GLT-1 expression, normalized the hyperactivity of lateral habenula neurons in slices, and reversed depression-like and anxiety-like behaviors in rats undergoing alcohol-withdrawal [88].