To assess influencing factors of microbiome structure on OTU level in addition to group membership, the impact of sex, age, BMI, cirrhosis, c-reactive protein (CRP), creatinine, INR, thrombocytes, bilirubin, markers of gut permeability, intestinal inflammation, bacterial translocation, bile acid composition and intake of the most common drugs (proton pump inhibitors (PPI), antihypertensives, non steroidal anti inflammatory drugs (NSAIDS), statins, beta blockers, thyroid medication and platelet function inhibitors) was assessed. This evidence concerns the gene CRP and Cirrhosis.