Zonulin and calprotectin in stool were not distinct between groups, but CRP was significantly higher in SC-CIP and CIP controls compared to healthy and in SC-CIP patients compared to cirrhosis (SC-CIP–healthy: p < 0.001; CIP controls–healthy: p = 0.016; Cirrhosis–SC-CIP: p = 0.04). Here, CRP is linked to hereditary sensory and autonomic neuropathy.