Univariate RDA analysis revealed that cirrhosis, PPI intake, beta blockers, statins, platelet function inhibitors, BMI, CRP, INR, calprotectin, zonulin, DAO, lipopolysaccharide-binding protein (LBP) and sCD14 were potential explanatory variables for microbiome composition with a p-value < 0.1. The gene discussed is CRP; the disease is Cirrhosis.