The screening of molecules that could interfere with the β2 adrenergic signaling allowed the identification of p38α and p38β MAPKs as suppressors of DUX4 expression in FSHD myotubes and myoblasts and animal models by a mechanism that still needs to be elucidated [33]. This evidence concerns the gene DUX4 and facioscapulohumeral muscular dystrophy.