Haemmig et al. reported that miR-125b mediated NF-κB activity by downregulating tumor necrosis factor alpha-induced protein 3 (TNFAIP3) and NF-κB inhibitor interacting RAS-like 2 (NKIRAS2), resulting in TMZ resistance in GBM cells. The gene discussed is NFKB1; the disease is glioblastoma.