TP53 and hepatocellular carcinoma: Additionally, studies have shown that miR-184 inhibits hepatocellular carcinoma cell proliferation and promotes hepatocellular carcinoma cell apoptosis by regulating the expression of AGO2 [11], and that miR-184 upregulates the expressions of P53 and P21 to inhibit the proliferation of human glioma and breast cancer cells [12].