NOS3 and hypertensive disorder: Although NG-nitro-L-arginine methyl ester (L-NAME) is a potent non-selective inhibitor of all three isoforms of NOS [eNOS, inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nMOS)], it has been widely used to induce hypertension due to inhibiting eNOS [12–14].