As a key transfer adaptor protein that transduces the Wnt3a/β-Catenin pathway, TRAF6 upregulated the mRNA expression of β-Catenin and subsequently activated Wnt target genes such as c-Myc and LRP5 in human prostate cancer PC3U cells [53] (Fig. 3). This evidence concerns the gene TRAF6 and Familial prostate cancer.