In many cancer cells, SF3B1 mutation was found to dysregulate multiple cellular functions, including heme biosynthesis, immune infiltration, DNA damage response, R-loop formation, telomere maintenance, and Notch signaling [74, 91–93], as well as many cellular pathways, such as the mitochondrial, Notch and NF-κB pathways [91]. The gene discussed is SF3B1; the disease is cancer.