Cell cycle checkpoints (G2M and E2F hallmark gene sets) and MYC signaling (MYC targets hallmark gene set) were enriched in proneural tumors, while the mesenchymal tumors were highly inflammatory (enriched inflammatory response, IL6/JAK/STAT3 signaling, coagulation, and interferonγ response gene sets). This evidence concerns the gene STAT3 and mesenchymal cell neoplasm.