As MGMT promoter methylation is correlated with survival outcomes in glioblastoma,5 it is plausible that unappreciated more widespread epigenetic modifications also exist and drive tumor progression.44 Studies have investigated global methylation in glioblastoma45; we propose that analyzing these patterns in CT may expose novel drivers of glioblastoma malignancy and provide modifiable therapeutic targets. This evidence concerns the gene MGMT and glioblastoma.