In such studies, four main polymorphisms in the Vdr gene: TaqI, BsmI, ApaI, and FokI have been linked to increased susceptibility to MS, TIDM, IBD, SLE, and RA.(130, 131, 132, 133, 134, 135) Association of the four VDR variants differs between population and disease, but the presence of SNPs in the VDR gene is common to GWASs of many T‐cell‐mediated inflammatory diseases. This evidence concerns the gene VDR and rheumatoid arthritis.