For instance, epigenetic inactivation of SERP genes allowed constitutive Wnt signaling pathway in colorectal cancer [25], while overexpression of Wnt genes (Wnt 3, Wnt5b, Wnt6, Wnt10a, Wnt14, and Wnt16) activated Wnt signaling pathway in Chronic lymphocytic leukemia [26]. Here, WNT6 is linked to B-cell chronic lymphocytic leukemia.