WNT16 and B-cell chronic lymphocytic leukemia: For instance, epigenetic inactivation of SERP genes allowed constitutive Wnt signaling pathway in colorectal cancer [25], while overexpression of Wnt genes (Wnt 3, Wnt5b, Wnt6, Wnt10a, Wnt14, and Wnt16) activated Wnt signaling pathway in Chronic lymphocytic leukemia [26].