Qu [8] firstly reported that downregulated MAC30 expression inhibited the breast cancer cell invasion and epithelial–mesenchymal transition (EMT) by suppressing Akt phosphorylation, β-catenin, survivin, and cyclin D1 in PI3K/Akt and Wnt/β-catenin signaling pathways. This evidence concerns the gene TMEM97 and breast cancer.