By contrast, in support of GPR55 agonists, two studies found that GPR55 knockout mice showed increased adiposity and insulin resistance associated with decreased locomotor activity (Meadows et al., 2016; Lipina et al., 2019), although another failed to demonstrate increased adiposity and locomotor activity was actually increased during the first six hours of the dark period (Bjursell et al., 2016). This evidence concerns the gene GPR55 and Insulin resistance.