Similarly, we also found that NRP1-KD restrained the migration and invasion capability of HRGC cells, and NRP1 was involved in circHIPK3 promotion of HRGC metastasis by the sponging with miR-653-5p and miR-338-3p, suggesting the metastatic promotion role of NRP1 in GC under a long-term hypoxic microenvironment. Here, NRP1 is linked to gastric cancer.