Reminiscent of the differential localization of CPs associated to the infection of animal DNA viruses, such as ssDNA Adeno-associated virus type 2 (Wistuba et al., 1997) and dsDNA human polyomavirus JC (Shishido-Hara et al., 2000), CP of a begomovirus tomato yellow leaf curl virus (TYLCV) is temporally excluded outside of the nucleolus in the progression of virus infection (Wang et al., 2017). This evidence concerns the gene CP and viral infectious disease.