Through the splicing mechanism, PRPF4, SRSF1, and HNRNPM regulate the cell proliferation, migration, and invasion in different cancers, including lung cancer (Choi, 2012; Chang and Lin, 2019), breast cancer (Anczuków et al., 2015; Sun et al., 2017; Park et al., 2019), cutaneous squamous cell carcinoma (Zhang et al., 2018), hepatocellular carcinoma (Tu et al., 2019), esophagus dysplasia (Varghese et al., 2015; Fitzgerald et al., 2018), gastric cancer (Wu et al., 2019), cervical cancer (Dong et al., 2019), and Ewing's sarcoma (Passacantilli et al., 2017). This evidence concerns the gene PRPF4 and cutaneous squamous cell carcinoma.