Finally, five SHGS, namely, pre-mRNA processing factor 4 (PRPF4), serine and arginine rich splicing factor 1 (SRSF1), heterogeneous nuclear ribonucleoprotein M (HNRNPM), DExH-box helicase 9 (DHX9), and origin recognition complex subunit 2 (ORC2), are identified between BE and EAC. The gene discussed is SRSF1; the disease is Barrett esophagus.