AQP1 and breast cancer: Recent studies reveal that miRNAs may act as oncogenes or suppressor genes in BC by participating in different cellular pathways (15, 16), including via targeting AQP1. Lately, miR-3194-3p was found significantly downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, which was associated with metastasis and recurrence of HCC through targeting BCL9 (17).