Building on a previous finding (Fang et al., 2013) that endothelial-specific knockdown of BRG1 attenuates atherosclerosis in mice by blocking leukocyte adhesion and vascular inflammation, we show here that BRG1 deficiency in endothelial cells ameliorates the loss of NO bioavailability. The gene discussed is SMARCA4; the disease is atherosclerosis.