The KO of TRPM2 suppressed microglial activation in the APP/PS1 transgenic AD mouse model (Ostapchenko et al., 2015) and involvement of astrocytic PARP-1 is also described by Aβ damage (Abeti and Duchen, 2012; Angelova and Abramov, 2014). Here, PARP1 is linked to Alzheimer disease.