MAPK8 and Alzheimer disease: In another transgenic mouse model of AD, the APPswe/PS1dE9 (AD-Tg) mouse, the administration of NMN lead to significantly decreased β-amyloid production, amyloid plaque burden, synaptic loss, and inflammatory responses through JNK activation, which was accompanied by a substantial improvement in behavioral measures of cognitive impairments compared to control AD-Tg mice (Yao et al., 2017).