Regarding a tannin suppressant PRR32, ESR1 activation in animal models of cardiac ischemia showed cardioprotective roles of ESR1 including reduction of inflammation, oxidative stress, and apoptosis of cardiomyocytes (Puzianowska-Kuznicka, 2012), but currently identified relations between ESR1 and PRR32 are inconsistent according to the network analysis. Here, ESR1 is linked to myocardial ischemia.