Because expression of proinflammatory cytokine tumor necrosis factor (TNF) in the heart leads to cardiac pathogenesis and congestive heart failure, and therefore attenuation or inhibition of TNF expression has been investigated as clinical strategies (Feldman et al., 2000; Hartman et al., 2018), the unknown function of ESR1 and PRR32 gains attention. This evidence concerns the gene ESR1 and congestive heart failure.