STAT3 and head and neck squamous cell carcinoma: Interestingly, in HNSCC, we also found angiogenesis in the CCND1 amplification phenotype, while the activities of the interferon-α/β response, interleukin (IL)6-Janus kinase (JAK)-signal transducer and activator of transcription (STAT)3 signaling, and Wnt-β catenin signaling pathways were increased in the neutral phenotype (Figure S5).