In the TME of TCGA pan-cancer cohort, CCND1 amplification showed a statistically significant correlation with high expression of TGFB1 (5.293 vs. 5.108, P < 0.0001), VEGFA (5.992 vs. 5.854, P = 0.0073), VEGFB (6.458 vs. 6.483, P = 0.1283), ICAM1 (4.721 vs. 4.896, P = 0.2596), and HIF1A (6.028 vs. 5.761, P < 0.0001) in the TME (Figure 4B and Figure S6). Here, HIF1A is linked to cancer.