This led to the approval of therapeutic inhibitors of programmed cell death 1 (PD-1) pathway, pembrolizumab, nivolumab, and cemiplimab, and of the programmed cell death ligand 1 (PD-L1) pathway, atezolizumab, durvalumab, and avelumab, by the US Food and Drug Administration (FDA) for the treatment of advanced melanoma, non-small-cell lung cancer, renal cell carcinoma, head and neck squamous cell carcinoma (HNSCC), Hodgkin's lymphoma, squamous cell cancer of the skin, and urothelial bladder cancer. This evidence concerns the gene PDCD1 and skin squamous cell carcinoma.