We analyzed CCND1 amplification of 6,536 patients from the Geneplus 1,021 panel in a Chinese population and found that HNSCC had a high CCND1 amplification in 25.00% of the cases (7/28), followed by ESCA in 23.88% (16/67), BLCA in 9.76% (8/82), and melanoma in 6.67% of cases (6/90) (Figure 1A and Table S2). This evidence concerns the gene CCND1 and head and neck squamous cell carcinoma.