Especially the combination of chemoradiation, EGFR-inhibition and the anti-VEGF antibody bevacizumab has been tested in different entities but efficacy so far appears limited: In HNSCC, the addition of bevacizumab to radiation, cetuximab and pemetrexed was reported to increase toxicity without an apparent improvement in efficacy (138). This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.