IL1B and type 1 diabetes mellitus: NLRP3 inflammasome activation by mitochondrial DNA promotes IL-1β release, contributing to the generation of pathogenic Th17/Th1 cells in the PLNs, and increasing T1D susceptibility in STZ-induced T1D model; NLRP3 deficiency in NOD mice inhibits the expression of chemokines and chemokine receptors involved in immune cell migration to pancreatic islets of NOD mice, which protects NOD mice against T1D development.