In accordance, an association study in a north-eastern Brazilian population identified two single-nucleotide polymorphisms (SNPs) in NLRP3, rs10754558, and rs358294199, that are associated with T1D in humans, suggesting that variations in NLRP3 may be a predisposing genetic factor for the development of autoimmune T1D (89). The gene discussed is NLRP3; the disease is type 1 diabetes mellitus.