Concomitantly, the inhibitory kinase, BCKDK, was augmented in the obese patients (compared to non-obese) whereas, activating phosphatase PPM1K (protein phosphatase Mg2+/Mn2+ phosphatase) levels were reduced in morbid obesity (compared to both non-obese and pre-obese patients) (Figure 2B). The gene discussed is PPM1K; the disease is morbid obesity.