TGFB1 and central nervous system cancer: Neutralizing TGF-β in the brain TME rescued NK cell anti-tumor function in glioma or medulloblastoma patients (45, 46) and expression of a dominant negative TGF-β receptor lacking the kinase domain (80) restored NK cell cytotoxicity against GBM and medulloblastoma cells in the presence of TGF-β in vitro (46, 81).