FLT3 and Timothy syndrome: Recently, a largest-ever genome-wide association and family co-segregation studies with 4,819 TS case subjects and 9,488 control subjects have found only one significant locus (FLT3 on chromosome 13, rs2504235, with odds ratio = 1.16), and TS polygenic risk scores could significantly predict both TS and tic spectrum disorders status in the population-based sample (40).