CDK5 and Alzheimer disease: ERK and CDK5 activation have been closely implicated with the progression of AD pathology and unbalanced mitochondrial dynamics, and inhibition of these proteins have been regarded as a potential strategy for AD therapeutics (Cruz et al., 2006; Cagnol and Chambard, 2010; Ha et al., 2012; Gan et al., 2014; Giese, 2014).