Mutations in GRN have been associated with various neurodegenerative and neuroinflammatory disorders, including AD, ALS, Creutzfeldt–Jakob disease, and viral infections of CNS (Johnston et al., 2001; Malaspina et al., 2001; Baker and Manuelidis, 2003; Ahmed et al., 2007). The gene discussed is GRN; the disease is Alzheimer disease.