Correcting ATP deficits in Trem2-deficient microglial cells through cyclocreatine treatments restored the microglial response to Aβ plaques in AD mice, indicating that metabolic deficits are the primary cause of dysfunctional microglial responses regulated by Trem2 in AD (Keren-Shaul et al., 2017). This evidence concerns the gene TREM2 and Alzheimer disease.