More and more reports have shown that m6A regulators such as METTL14 (Li et al., 2020), YTHDF1 (Zhao et al., 2018), YTHDF2 (Chen et al., 2018), and WTAP (Chen et al., 2019) are essential for the deterioration and the progression of HCC. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.