Therefore, GLUT1 dysfunction contributes to a variety of CNS diseases, termed GLUT1-deficiency syndromes (Glut1-DS), such as drug-resistant epileptic seizures, psychomotor retardation, ataxia, and microcephaly (Galochkina et al., 2019; Koch and Weber, 2019). The gene discussed is SLC2A1; the disease is Dravet syndrome.