Importantly, Rab4 blockade with 3-PEHPC leads to Drp1 restoration and reverses mitochondrial accumulation as well as antinuclear antibody (ANA) production, proteinuria, and LN in lupus-prone mice, identifying negative regulation of Rab4 as a potential target for promoting mitophagy in treatment of SLE (Caza et al., 2014). This evidence concerns the gene DNM1L and systemic lupus erythematosus.