Rapamycin prevents the development of LN in lupus-prone mice (Lui et al., 2008) and SLE patients (Fernandez and Crow, 2018; Eriksson et al., 2019) by inhibiting mTOR and enhancing autophagosome formation and autolysosomal degradation (Chen and Fang, 2002). The gene discussed is MTOR; the disease is systemic lupus erythematosus.