Proteogenomic analysis associated DNA mutations (data obtained from TCGA) to protein signaling to pinpoint the genetic drives of cancer, and revealed new signaling pathways for the breast cancer subtypes with specific mutations (PIK3CA and TP53) and identified two candidate markers (SKP1 and CETN3) in basal-like breast cancer (Mertins et al., 2016). The gene discussed is TP53; the disease is cancer.