BDNF and Anxiety: While TS increased Bdnf hippocampus levels and improved memory and anxiety behaviors in normal and depressive-like animals (Antoniazzi et al., 2017; Roversi et al., 2019), transgenic overexpression of Bdnf in the amygdala facilitated the development of anxiety-related behaviors (Govindarajan et al., 2006), thus showing the importance of the modulatory effect of Bdnf in the brain.