TARDBP and amyotrophic lateral sclerosis: On the other hand, rofecoxib might not significantly prolong the survival of SOD1G93A mice to a large extent if the drug exerts its effects via other genes, such as tdp43, Fus/TLS, c9orf72, etc. Therefore, establishing a better experimental model of ALS with more chronic disease process like human patients will be useful for testing the clinical translation of potential drug candidates.