On the other hand, rofecoxib might not significantly prolong the survival of SOD1G93A mice to a large extent if the drug exerts its effects via other genes, such as tdp43, Fus/TLS, c9orf72, etc. Therefore, establishing a better experimental model of ALS with more chronic disease process like human patients will be useful for testing the clinical translation of potential drug candidates. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.