TARDBP and amyotrophic lateral sclerosis: Based on this observation, more than 30 different mutated pathogenic genes, including cyclooxygenase-2 (COX-2) (Drachman et al., 2002), tdp43 (TARDNA Binding Protein 43) (Neumann et al., 2006), Fus/TLS (Fused in Sarcoma) (Vance et al., 2009), and c9orf72 (Chromosome 9 Open Reading Frame 72) (DeJesus-Hernandez et al., 2011), were found to participate in regulating ALS over the next 20 years (Renton et al., 2014; Young et al., 2014).