CAGE1 and cancer: Cancer associated genes such as MageE1, Morc2b, Morc4, Cage1, Brdt, IL13ra1, were expressed at significantly higher levels in KP-LC than WT-iPSCs (Figure S2A) and these genes were enriched in several pathways associated with cancer, including the PI3K-Akt signaling pathway, cancer proteoglycans, the Ras signaling pathway, cancer associated MicroRNAs, the Rap1 signaling pathway, HTLV-1 infection, the MAPK signaling pathway and ECM-receptor interactions (Figure S2C).