DENV infected GCN2−/− MEFs exhibited greater dsRNA staining in the cytoplasm suggesting greater accumulation of dsRNA in the cytoplasm of GCN2−/− MEFs as compared to WT MEFs upon DENV-2 (Figures 1I,J) infection as well as other DENV serotypes (DENV-1 and DENV-4) (Figures S1C,D). This evidence concerns the gene EIF2AK4 and infection.