Multivariate analysis also showed that increased mRNA expression expressions of HLA-DPB2 (HR = 0.66, 95% CI: 0.51–0.86, and P = 0.002) and HLA-DPB1 (HR = 0.996, 95% CI: 0.9928–0.9995, and P = 0.025) were independently associated with better OS of BC patients (Supplementary Table 3 and Supplementary Figure 4). Here, HLA-DPB2 is linked to breast cancer.