To this aim, we selected four breast cancer cell lines of TNBC, including the BRCA1 mutant cell line MDA-MB-436 (basal-like), and the BRCA1 wild type lines with BRCA1 allelic loss but normal transcript levels MDA-MB-468 (basal-like), MDA-MB-231 (claudin-low) and MDA-MB-453 (LAR-subtype). The gene discussed is BRCA1; the disease is breast carcinoma.