Recently, a new parthenolide derivative, dimethylamino-parthenolide, has been reported to inhibit the Nuclear chain factor kappa‐light‐chain enhancer of activated B cells (NF-κB) pathway and causes depletion of glutathione levels; the latter causing cancer cells to be more susceptible to oxidative stress‐induced cell death (Pei et al., 2009; Lamture et al., 2018). Here, NFKB1 is linked to cancer.