Therefore, we first constructed DTT-FDwt and DTT-FDmut by fusing the wild type and the mutant type (containing G12D) of KRAS G-domain, respectively, to the C-terminal of DTT via a GS linker (Figure 1A), and assessed their Anti-Tumor efficacies following the vaccination procedure displayed in Figure 1B. This evidence concerns the gene KRAS and neoplasm.