IFN-γ, as a typical Th1 cytokine, plays a vital role in the Anti-Tumor activities (37); therefore, we assessed the expression of SP-specific IFN-γ in CD4+ T and CD8+ T cells isolated from DTT-SP4- or DTSP-immunized mice after re-stimulation with SP in vitro. The gene discussed is CD4; the disease is neoplasm.