In AD, CXCL-10 has been found to bind to the chemokine receptor CXC chemokine receptor 3, which is involved in T cell initiation and maintenance of natural killer cells in the body, thereby inducing extracellular signal-regulated kinases Pathways eventually lead to neuronal dysfunction and apoptosis (Nelson and Gruol, 2004; Sui et al., 2006; Cho et al., 2009). Here, CXCL10 is linked to Alzheimer disease.