Other studies have demonstrated that SNAIL can promote the occurrence of epithelial-mesenchymal transition via the Dock1/NF-kB/SNAIL pathway in breast cancer (25), via the AKT/GSK-3ß/SNAIL pathway in colon cancer (26), via the Eif4E/SNAIL pathway in nasopharyngeal carcinoma (27), and via the PI3K/AKT/SNAIL pathway in head and neck squamous cell carcinoma (28). Here, AKT1 is linked to malignant colon neoplasm.