For example, relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) patients who were previously administered blinatumomab, a bispecific antibody that targets CD3 on T cells and CD19 on B cells, were less likely to achieve minimal residual disease deep remission and were more likely to experience relapse due to antigen loss after treatment with anti-CD19 CAR T cells (125). The gene discussed is CD19; the disease is acute lymphoblastic leukemia.