MIF has been found to be expressed in the neocortex, hippocampus, hypothalamus, cerebellum, choroid plexus, and spinal cord in the CNS (Nishibori et al., 1997; Bacher et al., 1998; Ogata et al., 1998; Vedder et al., 2000; Zhang et al., 2019) and up-regulated in AD and Parkinson disease (Nicoletti et al., 2011; Zhang et al., 2019). The gene discussed is MIF; the disease is Alzheimer disease.